Quinacrine

The controversial chemical sterilization method

Quinacrine is an old drug, originally used to treat malaria in the Second World War. A pair of US doctors discovered that it also caused scarring of tissue, and thought of using it as for sterilization. The technique consists of inserting several small pills into the top of the uterus. There they dissolve, creating scar tissue in the upper womb and nearby fallopian tubes which should block the fallopian tubes and thus prevent conception.

Advantages:
It is cheap, costing less than $1 per sterilization.
It can be performed by paramedical staff.
It does not require hospitalization or anesthesia (though it can be painful!), and therefore many women can continue working.
Concerns:
No two women respond identically to the drug, making it hard to design a 'good' dosage.
There is no inexpensive or non-invasive method of checking whether it worked. If the woman gets pregnant later, it's a failure. Otherwise, no one knows if it's a success.
Possible indications that quinacrine is a carcinogen.
Anti-immigration groups in the US are among the proponents of quinacrine.

Newsclips and info

India bans quinacrine. 10 Jan 99.
FDA bans quinacrine. 22 Oct 98.
Original FDA report, Aug 98. (PDF format)
FDA fines drug maker for marketing quinacrine online. Dec 97. and FDA warns consumers not to purchase sterilization kits online.
Description, mechanism of action and pharmacokinetics of quinacrine from Clinical Pharmacology Online.
US-banned sterilisation drug sent to Third World. AP, Jun 98.
Quinacrine in India. Population Research Institute, Aug 97.
Row over sterlisation divides India. New Scientist, April 97.
Under the operation table. Indian women should not be used as guinea pigs, according to Justice Anand. Indian Express, 10 April 1998.
Quinacrine in Vietnam. 3 July.
Indian activists demand action against US doctors. 13 July.
Govt drags feet on quinacrine threat 24 July.
(Indian) Govt. bans Quinacrine. 17 Aug.


I've attempted to write a neutral description of the quinacrine story here. All errors and misunderstandings are mine alone, and I would appreciate them being brought to my attention.
Susan Chacko

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